On December 4 and 5, a who’s who of Illinois health leaders participated in a workshop organized by Drs. Will Sander and Sulagna Chakraborty from the University of Illinois College of Veterinary Medicine. The workshop sought to anticipate and solve health challenges in the state using a “One Health” approach. During the workshop, participants assessed the needs in Illinois related to zoonotic diseases and outbreak response, agriculture and animal husbandry, environment, climate change, access to healthcare, antimicrobial resistance, and data interoperability.