This plenary discussion on One Health will be held at the 2018 Science Forum South Africa (SFSA2018), annually attended by thousands of delegates from all spheres of life. The informal approach of this event is meant to ignite conversations about science and educates ordinary citizens about pertinent global issues from different fields of science. Our panel of experts will share their insights and advise on zoonosis, antimicrobial drug resistance, and public health responsibilities of all citizens, while engaging and addressing questions arising from the floor.