Pathogenic microorganisms have been more harmful in human history than wars. This threatening process has peaked with COVID-19, but it won’t be the end. Why? In the twenty-first century, in the process starting with SARS and continuing with COVID-19 in 2020, five Zoonotic Pandemic Outbreaks have occurred. The death of more than 1,300,576 people in 11 months is sad and thought-provoking. Humanity could not stop the SARS-CoV-2 virus, which was born from the synergy of ecological and anthropogenic factors. Why?